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      【药名】左归丸 Zhuche Wan

      【处方熟地200克、山药100克、枸杞100克、山茱萸100克、牛膝75克、鹿角胶100克、龟板胶100克、菟丝子100克。

      【组方分析】方中重用熟地滋阴填精,大补真阴,为君药。山茱萸养肝滋肾,涩精敛汗;山药补脾益阴,滋肾固精;枸杞补肾益精,养肝明目;龟、鹿二胶,为血肉有情之品,峻补精髓,龟板胶偏于补阴,鹿角胶偏于补阳,在补阴中配补阳药,取“阳中求阴”之意,均为臣药。菟丝子、川牛膝益肝肾,强腰膝,健筋骨,俱为佐药。诸药合用,共奏滋阴补肾,填精益髓之功。

      【功能主治】滋肾补阴。用于真阴不足,腰酸膝软,盗汗遗精,神疲口燥。

      【制备方法】以上八味,除鹿角胶、龟板胶外,其余熟地黄等六味粉碎成细粉,过筛混匀。取鹿角胶、龟板胶烊化,与上述细粉混匀。每100克粉末加炼蜜10克与适量的水泛丸,干燥,即得。

      【剂型规格】水蜜丸,每10粒重1克。

      【用法用量】口服。一次9克、,一日2次。

      【质量控制

      1.本品为黑色水蜜丸;气微腥,味酸、微甜。

      2.应符合丸剂有关的各项规定。

      【使用禁忌】脾虚泄泻者慎用。

      【现代研究】本品能调节神经一内分泌功能,改善物质代谢,增强非特异性免疫功能。实验表明,左归丸可诱导大鼠骨髓源ASC向神经元样细胞或神经胶质样细胞方向分化。左归丸能减缓卵巢早衰小鼠外周血卵泡刺激素升高,雌二醇降低,使生长卵泡及成熟卵泡数增加,说明左归丸能改善卵巢免疫性炎症的损伤,对免疫性卵巢早衰具有治疗作用。左归丸能使环磷酰胺诱导小鼠白细胞降低模型的骨髓有核细胞计数、脾脏指数、胸腺指数、脾集落形成单位、血清粒细胞集落刺激因子有不同程度提高,表明左归丸对环磷酰胺所致的白细胞降低具有保护作用,该作用可能与升高血清粒细胞集落刺激因子有关。

      【临床应用】临床用于男、女生殖系统疾病,慢性肾炎,再生障碍性贫血,神经衰弱及腰肌劳损等属肾阴虚、阴虚内热或阴阳两虚证候者。

      【方歌】左归丸补肾阴虚,熟地山萸药枸杞,龟胶鹿胶菟牛膝,阳中求阴有深义。

      【贮藏】密封,置于阴凉处。



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